Nicotine Replacement Therapy

About Nicotine Replacement Therapy

Nicotine Replacement Therapy, Even if you’re a smoker or know somebody who is, it’s exceedingly difficult to quit. Tobacco products, such as cigarettes, contain nicotine, which is highly addicting. Cigarette addiction is a result of nicotine altering your brain chemistry. Withdrawal symptoms occur when your body does not obtain the amount it is used to receiving.

When you’ve given up smoking for a few weeks, your withdrawal symptoms should subside on their own. However, if you’re having trouble quitting, you may want to consider utilizing a nicotine replacement therapy. An item like gum or a skin patch can actually provide you with a small amount of nicotine. You’ll still get some nicotine in your system, but you won’t be exposed to any of the other hazardous compounds found in tobacco.

You won’t be able to get rid of your emotional attachment to smoking with a nicotine replacement. However, it can help alleviate your cravings and symptoms of withdrawal so that you can be focused on breaking your mental addiction rather than the physical one. Sublingual pills and gum are also forms of nicotine replacement therapy (NRT), as are transdermal patches and nasal sprays. A lessening of cravings & withdrawal symptoms can be achieved by providing a smoker with a nicotine substitute. Using any type of NRT can improve quitting by 50%–70%. Individuals who receive additional support appear to benefit from this impact, regardless of how much they receive. 

Research shows that a combination NRT, using a fast-acting form with a patch to help smokers quit, is more effective than using a single form of NRT to help smokers quit. A primary purpose of nicotine replacement therapy (NRT) is to alleviate nicotine withdrawal symptoms as the user quits smoking by supplying nicotine without using tobacco. Electronic cigarettes are not included in the first-line NRT.


Gastrointestinal problems (nausea, vomiting, abdominal discomfort, and diarrhea), headache, & local irritation may occur depending on the distribution route of the NRT product. In the event that NRT products cause negative effects, users can either adjust their dosage or switch to another brand. Below, we examine the NRT side effect profile for each specific kind.

It’s common for patients to worry that they’ll become addicted to nicotine replacement therapy (NRT), but this seldom happens. Additionally, patients may be concerned that nicotine promotes cancer, it does not, although it is a common myth.


A number of studies have shown that nicotine replacement therapy (NRT) is an effective way to quit smoking. Individual NRT drugs have been found superior in randomized studies to placebo, improving quitting rates by as much as threefold. There’s no difference in efficacy amongst NRT medicines in a randomized trial with a general population, including patches, gum, inhalers, and nasal sprays. There are separate sections on the efficacy of NRT for people with severe mental illness. (See “Nicotine replacement therapy” in “Modifiable risk factors for heart disease in people with a severe mental disorder.”)

Single-agent NRT has been found to be less effective than combinations of the long-acting patches and a short-acting form such as gums, lozenge, or inhaler by the majority of clinical trials. Nicotine patches paired with short-acting NRT products (gum, spray, or inhaler) were found to be more successful than a single kind of NRT in a meta-analysis of 14 randomized studies. Single product therapy was also found to be less successful than combination NRT. There were no differences in biochemically verified rates of smoking abstinence among the three groups in one randomized trial of 1086 smokers that evaluated 12 weeks of individual NRT (nicotine patch), combination NRT (nicotine patch with nicotine lozenge), and varenicline.

Furthermore, NRT appears to assist men more often than women in some studies, but this is not universal. Administration — We recommend a mix of long- and short-acting NRT as a first therapy for tobacco smokers who intend to use NRT.

For smoking cessation, mixing NRT drugs makes sense because of variances in the bioavailability of NRT products. A combination of NRT medicines can be utilized because each agent creates a lower blood nicotine level than if you smoked a pack of cigarettes every day. People who smoke already know how to regulate their nicotine levels to avoid nicotine withdrawal & nicotine overdose because they’ve been doing it for years as cigarette smokers. Smokers already know how to accomplish this.

For most Nicotine Replacement Therapy medications, the initial dosage is based on the number of cigarettes smoked each day. The dosage of NRT is then gradually reduced. For the most part, NRT use is recommended for two to three months after smoking cessation, but it is allowed to continue NRT for as long as an individual is at risk of relapse because Nicotine Replacement Therapy is significantly safer than smoking. Some persons may need to continue using the products for the rest of their lives. The transdermal patch can also be administered while a smoker is still smoking in order to help them kick the habit.

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