Stem Cell Therapy

Regarding Stem Cell Therapy:

Stem Cell Therapy Bone marrow and stem cells are transplanted into the body. Stem cell transplants replace stem cells that have been killed in the bone marrow by disease, chemotherapy, or radiation. The transplant procedure has different names depending on where the stem cells come from. Blood stem cell transplantation from the body’s edges

A Transplant Of Cord Blood

Stem Cell Therapy, All of these are called transplants of hematopoietic stem cells. In a normal stem cell transplant for cancer, very strong doses of chemotherapy are sometimes used with radiation therapy to try to kill all cancer cells. This therapy also kills the stem cells in the bone marrow. Myeloablation, or myeloablative therapy, is the name for this process. Shortly after treatment, stem cells are given (transplanted) to replace the ones taken away. Like a blood transfusion, the new stem cells are put into a vein. The transplanted cells should start to grow and make healthy blood cells once they settle in the bone marrow. This process is called “engraftment.” These are the two main types of transplants. They get their names from the person whose stem cells were used to make them. Auto is the Latin word for “self.” In autologous transplantation, the person who will get the transplant is also the donor, and this is because the stem cells come from the same person who will get the transplant. Allogeneic is just a word that means “other.” Allogeneic transplants use stem cells from a donor instead of the patient’s own, and the donor could be a family member or someone unrelated to the patient.

Autologous Stem Cell Transplantation

The first step in this kind of transplant is to get your stem cells out of your body. Your bone marrow or blood is used to remove and freeze your stem cells. As part of your myeloablative therapy, your stem cells are frozen and given back to you after you have had a lot of chemotherapy and radiation.

Benefits Of Autologous Stem Cell Transplant

One benefit of an autologous stem cell transplant is that you can get your cells back. When you get your stem cells, you don’t have to worry about your body rejecting the engrafted cells, also called the “graft.” One autologous stem cell transplant risk is graft failure, which keeps the transplanted stem cells from getting into the bone marrow and making blood cells. The “graft-versus-cancer” effect cannot happen with autologous transplants. The problem with an autologous transplant is that cancer cells are taken out of your body and the stem cells are then put back in. Another problem is that your immune system is still the same as before the transplant, which means that the cancer cells might be able to survive another attack by the immune system. Multiple myeloma, lymphomas, and some types of leukemia are the most common diseases that this type of transplant is used to treat. It is sometimes used to treat neuroblastoma, testicular cancer, and several types of cancer in children. Autologous transplants can also treat diseases like systemic sclerosis, multiple sclerosis (MS), and systemic lupus erythematosus.

Eliminating Malignant Cellular Remnants From Autologous Transplant Stem Cells

Stem Cell Therapy, Some places treat the stem cells before giving them back to the patient so that any cancer cells that may still be there don’t get passed on. This could also be called cleaning. Even though this might help some people, there haven’t been enough tests to know if it works. During the purging process, some healthy stem cells may be lost. Because of this, your body might take longer to start making normal blood cells and you might have dangerously low levels of platelets or white blood cells for a long time. This can make it more likely that you will get an infection or have trouble with bleeding.

Anti-cancer drugs given after the transplant are another way to help get rid of any cancer cells that may be in the stem cells that come back. Stem cells are never touched. After the transplant, the patient is given drugs that kill any cancer cells that are still in their body. It is known as “in vivo purging.” For example, the drug lenalidomide can be used to treat multiple myeloma. Still, being studied is the best. way to get rid of cancer cells in people who have had stem cell transplants or transplants.

Two Transplants At Once (Double Autologous)

A tandem or double autologous transplant is when two autologous transplants are done, one right after the other. As part of myeloablative therapy, the patient gets two high-dose rounds of chemotherapy, followed by a transplant of their stem cells after each round. Before the first high-dose chemotherapy treatment, all needed stem cells are taken, and half of them are used for each transplant. Most of the time, six months pass between the two chemo sessions. After the first dose has helped the person feel better, the second dose is given.

Tandem transplants are now the standard way to treat several types of cancer. Tandem transplants work well for adults with high-risk multiple myeloma and children with neuroblastoma. But experts don’t agree on whether a combination of treatments is better than a single transplant for some types of cancer. Because this treatment requires two transplants, there is a higher chance of side effects than when only one transplant is done. Tandem transplants are also both autologous transplants and transplants from different people. Mini-transplants are talked about in more detail below.

Stem Cell Therapy, Donor stem cells are used in allogeneic stem cell transplantation. Most allogeneic transplants use stem cells from a donor whose tissue is genetically similar to yours. Most of the time, a brother or sister is the best donor. If no one in your family is a good match, you may be able to find a donor from the general population through a national registry. This is also called a MUD transplant, or a “matched unrelated donor.” Most of the time, MUD transplants are riskier than transplants that use a close relative who is a good match. An allogeneic transplant is like an autologous transplant in how it works. Stem cells from donors are separated, frozen, or stored. As part of your myeloablative therapy, you get a lot of chemotherapy and radiation. After that, the donor’s stem cells are frozen and given to you.

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